& (1983). (2002). (2004). (2005). (2006). (2007). (2009). (2011). (2012). (2013). (2014). (Beninger, (Bremner, (Downar (Dunlop (Heller ... 1151-1159. 12(4), 1228-1236. 163(10), 166(6), 170(2), 173-196. 176-185. 1784-1790. 197-206. 2002). 2004). 2007; 2011). 2011; 2012). 2013; 2014; 2018; 2019). 2019; 2020; 26(5), 273-279. 327-337. 331. 334-342. 469(7328), 483. 5(6), 51(4), 53. 59(12), 6(2), 62(11), 64(3), 677-688. 70(4), 702-710. 76(3), A A. A., Adil, Adli, Akil, Although American An Anhedonia Archives B. B., Beninger, Bermpohl, Biological Birk, Bogdan, Brain Bremner, Busto, Butler, C. C., Carlezon, Charney, Chusid, Circuit Clark, Czuj, D. D., Davidson, Depression Dillon, Disrupted Dopamine Dopamine, Downar, Dunlop, E. E., Epstein Epstein, Exploring F., Fava, Flagel, Flint, Focus Functional G. G., Geraci, Goetz, Gong, Graham, H. H., He, Heller, Hence, Herrmann, Hevenor, Holmes, Huang, Hyporeactivity Hägele, I., Interestingly, It J. J., Johnstone, Journal K., Kalin, Khan, Kocsis, Kolden, Kuang, L. L., Lack Light, M. M., Mason, Mayberg, Mayo, McAndrews, Molecular Mood N. N., Naranjo, Nature Nature, Nazeer, Nemeroff, Nestler, Nevertheless, On One Overall, P., Pan, Peterson, Pizzagalli, Psychiatry, Q. Q., R. R., Reduced References Relationships Research Reviews, Reward Robinson, Ruhé, S. S., Salomons, Schene, Schlagenhauf, Should Silbersweig, Since Sterzer, Stoy Stoy, Such Suchotzki, T. T., The This Tremblay, U. V., Vermetten, Vythilingam, W. W., Wang, We Wheeler, Willuhn, Wise, Wu, X., Y., Yang, Zhang Zhang, a abnormalities about account accumbens accumbens. accuracy action activate activation activity additional adulthood. advanced affect after al., along also altered an anatomical and and/or answer antidepressant are area as aspects assess associated attempts attention be been beginning being belongs benefiting between both bottom-up brain brain's brain’s bring by can caudate causality causality. certain challenges challenging changes characteristic circuit circuits. class clusters commences compared complexity concepts confidence. connection connectivity considers correlation cortex cortical could covert critical cues current daily dampened decreased delves demonstrated depletion depressed depression depression, depression. depressive design determine development develops different difficult diminished direction discovered discrete disorder disorder. distinguish dopamine dopaminergic dorsomedial draw drug drug-naive, due dynamic dysfunction dysfunctional dysregulation dysregulation, dysregulation. e effect efficacy element elements emotional emphasizing entails equally escitalopram. et evaluation, evidence examining exhibited exposure external far-reaching finding first-episode five fluctuation for four from fronto-striatal function functional functioning functioning. functions fundamental general greater hand, has have healthy hence hierarchical highly humans: hyporeactivity imaging impact impaired implication implies important improvement in inadequate incentive increased indirectly individual individual's individual. individuals individuals, individuals. insight interaction interconnected internal interpretation intervention interventions into involved is it its key known lasting leads learning learning. level level, levels levels. like likely limbic limbic-cortical limbic-subcortical localized locomotor long-term low macro magnetic major majorIncreasing measure mechanism medication. mental mesolimbic meta-analysis methodology micro model modification modifications, modulated monoamine monoamines mood more motivation, motivation. movement much multi-faceted necessary negative negativity network network, networks networks. neural neuroanatomical neurochemical neuronal neurons neurophysiopathologist neuropsychological neuropsychopathology neuroscience, neurotransmitter neurotransmitters nonresponders norepinephrine normal normalizes nucleus number of offer on onIncreasing one one's ones opposed opposing or orbitofrontal order other our over overt part participants. particular particularly pathophysiology pathway pathways patients paying perception performance periods pharmacological physical play positive positivity positivity. possible post-dysfunctional precedence prefrontal probable probe. process processes processing produce produced produces progression psychiatry, psychopharmacology, question raise received reduced region region-wide region. regions reinforcement related relation relevant remains repetitive required research responders response responses responsible restore resulting results revealed reversed reversibility reviews reward reward-circuit rewarding rewards role said sample see seems selective selectively sensitive sensitivity serotonin serotonin, short-lived short-term should shown significant singular six stage-wise standard still stimulation stimuli stimuli, stimulus–reward strategies striatal striatum structural studies studies. study subjected subjects subjects. substrates such suggest sustained symptom system taken targets temporal tested, than that the them themes then this three thus time time-course to towards transcranial transient treatment treatment, treatment. turn two underexposure understanding unify units unmedicated useful utilize valence, variable variation variety ventral versus volume well-balanced whether which widely with workings would yet