STRUCTURAL BIOLOGY IN PHARMACEUTICAL RESEARCH Molecular biology plays a key role and contributes a lot in determining the 3D structure of a molecule be it proteins, nucleotides, or any other biologica
STRUCTURAL BIOLOGY IN PHARMACEUTICAL RESEARCH Molecular biology plays a key role and contributes a lot in determining the 3D structure of a molecule be it proteins, nucleotides, or any other biologica
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STRUCTURAL BIOLOGY IN PHARMACEUTICAL RESEARCH
Molecular biology plays a key role and contributes a lot in determining the 3D structure of a molecule be it proteins, nucleotides, or any other biological macromolecule. It also helps in finding the target sites when it comes to drug designing. Many structural biology techniques are used in the field of pharmaceutical research. These mainly include X-ray crystallography and NMR Spectroscopy. However, structural biology also includes the help of bioinformatics.
Structure based drug design plays a major role when it comes to pharmaceutical research and also it has advanced a lot over the years. The remarkable discovery of peptidomimetics and nonpeptides proves this. This was done using techniques like X ray crystallography and NMR spectroscopy as well as other computer based methods. One of the widely used tools in structural biology is X-ray crystallography. This is used to determine the atomic as well as the molecular structure of a crystal where the crystalline atoms cause diffraction of X-rays in many specific directions.
It is a form of high resolution microscopy. Using this technique, visualizing protein structures at the atomic level becomes easier and helps in understanding its functions. It also gives information about how proteins react with other molecules and undergo changes in their conformation. As well as the