PRODUCTION OF MUTANT BASED EPSILON TOXIN (ETK) VACCINES Vaccines improve the immune system of an animal or human by stimulating the production of antibodies to fight and combat bacteria, proto

PRODUCTION OF MUTANT BASED EPSILON TOXIN (ETK) VACCINES Vaccines improve the immune system of an animal or human by stimulating the production of antibodies to fight and combat bacteria, proto

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PRODUCTION OF MUTANT BASED EPSILON TOXIN (ETK) VACCINES         3346 WORDS

CRITIQUE OF LI ET AL. ARTICLE: A LOW-TOXIC SITE-DIRECTED MUTANT OF CLOSTRIDIUM PERFRINGENS É›-TOXIN AS A POTENTIAL CANDIDATE VACCINE AGAINST ENTEROTOXAEMIA

Vaccines improve the immune system of an animal or human by stimulating the production of antibodies to fight and combat bacteria, protozoan or viruses effectively creating immunity against disease (Salisbury 1997). Vaccines commonly contain weakened or dead strains of a virus, bacteria or protozoan which elicits the body’s immune system upon recognition to respond by producing antibodies to fight against the invading antigen. In effect, the vaccine introduces the disease or its causative agent into the body to gain a defense response; as a result if the disease enters the body in the future the body can produce the requisite antibodies to fight the disease faster, as it remembers measures taken to fight against the disease previously. Consequently, the time taken to recognize the disease, provide active measure against the disease and minimize any possible signs or symptoms associated with the causative virus, bacteria or protozoan. Building on this function of vaccines this essay critiques the study and subsequent paper of Li et. al. investigation into the production of mutant based epsilon toxin (ETK) vaccines which can provide protection against intoxication.

Costridium perfringes a Gram positive spore forming bacterium, is ubiquitously found in the environment and the intestines of humans and animals. Furthermore, it is commonly found in raw meat